Product Name: Panamor – 100 SR Tablets
Generic Name: Diclofenac Sodium
Strength: 100 mg
Dosage Form: Sustained Release Tablets
Indications: Panamor – 100 SR Tablets are indicated for the treatment of pain and inflammation associated with various conditions, including:
- Rheumatoid arthritis
- Osteoarthritis
- Ankylosing spondylitis
- Acute musculoskeletal disorders
- Acute gout
- Postoperative pain
- Dysmenorrhea (painful menstrual periods)
Mechanism of Action: Diclofenac Sodium is a non-steroidal anti-inflammatory drug (NSAID) that works by inhibiting the enzyme cyclooxygenase (COX), which is involved in the production of prostaglandins. Prostaglandins are mediators of inflammation, pain, and fever. By reducing their synthesis, Diclofenac helps alleviate symptoms of pain and inflammation.
Dosage and Administration:
- The typical dosage is one 100 mg tablet taken once daily.
- Tablets should be swallowed whole with water and should not be crushed or chewed.
- It is recommended to take the tablet with or after food to reduce the risk of gastrointestinal side effects.
Contraindications:
- Known hypersensitivity to Diclofenac or any of the tablet’s excipients.
- History of asthma, urticaria, or allergic-type reactions after taking aspirin or other NSAIDs.
- Active or history of recurrent peptic ulcer/hemorrhage.
- Severe hepatic, renal, or cardiac failure.
Warnings and Precautions:
- Use with caution in patients with a history of gastrointestinal disease.
- Monitor for signs of gastrointestinal bleeding, ulceration, or perforation.
- May increase the risk of serious cardiovascular thrombotic events, myocardial infarction, and stroke.
- Use with caution in patients with hypertension or heart failure.
- Not recommended during the third trimester of pregnancy.
Side Effects: Common side effects include:
- Gastrointestinal discomfort (nausea, vomiting, diarrhea, constipation)
- Headache
- Dizziness
- Elevated liver enzymes
- Edema
Serious but rare side effects include:
- Gastrointestinal bleeding or ulceration
- Cardiovascular events (heart attack, stroke)
- Severe skin reactions (Stevens-Johnson syndrome)
- Hepatic dysfunction