Amiloretic is a medication that combines two active ingredients, amiloride and hydrochlorothiazide. It is used to treat hypertension (high blood pressure) and to manage edema (fluid buildup) associated with congestive heart failure, cirrhosis of the liver, and other conditions.
Amiloride works by preventing the reabsorption of sodium in the kidneys, while hydrochlorothiazide increases the excretion of sodium and water through the urine. Together, these two drugs help to reduce blood pressure and relieve fluid retention.
Dosage and Administration: The usual starting dose of Amiloretic is one tablet (50mg amiloride/5mg hydrochlorothiazide) taken once daily, with or without food. The dosage may be adjusted by a doctor based on individual response and medical condition.
It is important to take Amiloretic exactly as directed and not to exceed the recommended dose. If a dose is missed, it should be taken as soon as possible. However, if it is almost time for the next dose, the missed dose should be skipped and the regular dosing schedule should be resumed.
Side Effects: Amiloretic may cause side effects in some individuals. The most common side effects include nausea, vomiting, dizziness, headache, dry mouth, increased thirst, and fatigue. Less common but more serious side effects include electrolyte imbalances, kidney dysfunction, and liver dysfunction.
Precautions: Patients should inform their healthcare provider of any medical conditions they have, including allergies to medications or other substances, before taking Amiloretic. The medication should not be taken during pregnancy or while breastfeeding, and it should be used with caution in patients with kidney or liver disease, diabetes, gout, or electrolyte imbalances.
Drug Interactions: Amiloretic may interact with other medications, including lithium, digoxin, and other drugs that may increase potassium levels. It may also interact with medications that affect the heart rhythm, such as quinidine and procainamide.
Overall, Amiloretic is an effective medication for treating high blood pressure and fluid retention, but it should only be taken under the supervision of a healthcare provider, who can monitor for any potential side effects or drug interactions.